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Anyone who bothered to peek at old maps of the sixteenth century would discover that even then, in Sarnano, a spring with particular properties was known: the water of "Gnagnà" or San Giacomo.
No one remembered why it was called like that and everyone ended up convinced that it had something to do with San Giacomo della Marca, the famous preacher. In reality, next to that spring in the fourteenth century there was a hospital for pilgrims named after St. James the Apostle, but our history does not speak of this.
Whatever the saint in question was, the particularities of those waters ended up in oblivion and even when, at the end of the nineteenth century, a certain Dr. Cenni mentioned them in his Medical Topography, people continued to ignore them.
Source: https://www.termedisarnano.it/la-storia/